海军医学杂志

目的探讨盐酸羟考酮缓释片对老年晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的镇痛效果及对患者血清炎症因子水平的影响。方法选取2015年3月至2017年3月公安县人民医院收治的年龄大于60岁的老年晚期NSCLC患者100例,按照随机数字表法分为观察组与对照组,每组50例。对照组在常规化疗治疗的同时给予硫酸吗啡缓释片镇痛,观察组在常规化疗治疗的同时给予盐酸羟考酮缓释片镇痛。观察比较2组患者镇痛有效率、起效时间及不良反应发生情况;检测治疗前后2组患者血清中白细胞介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)水平。结果对照组患者治疗后镇痛总有效率为82.0%,镇痛起效时间为(2.51±0.23)h,不良反应发生率为36.0%;观察组患者治疗后镇痛总有效率为92.0%,镇痛起效时间为(0.87±0.11)h,不良反应发生率为24.0%。两者比较差异有统计学意义(P<0.05)。治疗后,对照组和观察组患者血清中IL-6及TNF-α水平均明显低于本组治疗前;观察组患者治疗后血清中IL-6及TNF-α水平均明显低于对照组治疗后,差异均有统计学意义(P<0.05)。结论盐酸羟考酮缓释片对老年晚期NSCLC患者具有较好的镇痛效果,具有起效时间短,不良反应发生率低,安全性高等优点,同时还可显著缓解患者炎性反应状态。

Objective To investigate the effects of oxycodone hydrochloride slow-release tablets on analgesia and inflammatory factors in old patients with advanced non-small cell lung cancer(NSCLC).Methods One hundred patients with advanced NSCLC with an age over 60 years who were admitted in People′s hospital, Gongan county for treatment from March 2015 to March 2017 were selected as research subjects and were randomly divided into the observation group and the control group, each consisting of 50 patients. The control group received morphine sulfate slow-release tablets for analgesia supplemented with conventional chemotherapy at the same time, and the observation group was given oxycodone hydrochloride slow-release tablets for analgesia supplemented with conventional chemotherapy. The analgesic efficiency, onset time and adverse reactions were observed and compared between the 2 groups. The levels of IL-6 and TNF-α in the serum of the patients in the two groups were detected before and after treatment.Results The total effective rate of analgesia in the control group after treatment was 82%, the onset time of analgesia was(2.51±0.23) h and the rate of adverse reactions was 36.0%, while the total effective rate of analgesia in the observation group after treatment was 92.0%, the onset time of analgesia was(0.87±0.11) h and the rate of adverse reactions was 24.0%. Statistical significance could be noticed, when comparisons were made between the 2 groups(P<0.05). Following treatment, the serum levels of IL-6 and TNF-α in the patients of both the control group and the observation group were significantly lower than those before treatment, and the levels of serum IL-6 and TNF-α of the patients in the observation group were significantly lower than those in the control group after treatment, also with statistical significance(P<0.05).Conclusion Oxycodone hydrochloride slow-release tablets could exert good analgesic effects on old patients with advanced NSCLC, and have the advantages of short onset time, low rate of adverse reactions and good safety, and at the same time it could significantly alleviate inflammatory reaction of patients.